- The hydroxylation of Δ5-androstenes by Cephalosporium aphidicola
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Whereas the major hydroxylation product of 3β-hydroxy-5α-androstan- 17-one by Cephalosporium aphidicola is the 11α-alcohol, the presence of a Δ5-double bond in the substrate leads to non-stereospecific allylic hydroxylation at C-7. Hydroxylation at C-11 became a minor transformation and there was no detectable hydroxylation at C-14.
- Bensasson, Caroline M.,Hanson, James R.,Hunter, A. Christy
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p. 2355 - 2358
(2007/10/03)
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- The Preparation and Dienone-Phenol Rearrangement of Androsta-2,5-diene-4,17-dione
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The preparation of androsta-2,5-diene-4,17-dione from dehydroisoandrosterone is described.Its dienone-phenol rearrangement, in the presence of hydrobromic acid and glacial acetic acid, affords 1-methyl-4-hydroxy-estra-1,3,5(10)-trien-17-one.
- Hanson, James R.,Raines, David,Knights, Steve G.
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p. 1311 - 1313
(2007/10/02)
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