cas 3418-45-9, 3-Quinolinol,1,2,3,4-tetrahydro-

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3418-45-9

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Double Hydroboration of Quinolines via Borane Catalysis: Diastereoselective One Pot Synthesis of 3-Hydroxytetrahydroquinolines
Described herein is an organoborane-catalysed consecutive borylative reduction of quinolines and isoquinolines to furnish tetrahydro(iso)quinolines bearing a C(sp3)?B bond β to the nitrogen atom. The installed C?B bond is oxidatively transformed to the hydroxy group in one pot. The present double hydroboration is proposed to proceed via a stepwise ionic mechanism involving a boronium ion. The stereo-outcome was found to be dependent on the position (C2 vs C4) of the substituents in quinolines. (Figure presented.).
Kim, Eunae,Jeon, Hyun Ji,Park, Sehoon,Chang, Sukbok
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p. 308 - 313
(2019/11/13)

β-Hydroxy-tetrahydroquinolines from Quinolines Using Chloroborane: Synthesis of the Peptidomimetic FISLE-412
A new synthetic protocol provides a simple and direct method to generate functionalized β-hydroxy-tetrahydroquinolines (THQs). Hydroboration of quinolines using chloroboranes followed by oxidation with NaBO3?H2O led to the formation of functionalized β-hydroxy THQs. High regio- and diastereoselectivities were observed in α and γ substituted quinolines and the trans diastereomer of the β-hydroxy-THQ was the major isostere. This new protocol was utilized to build the novel antibody-targeted lupus peptidomimetic, FISLE-412.
Altiti, Ahmad S.,Cheng, Kai Fan,He, Mingzhu,Al-Abed, Yousef
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p. 10738 - 10743
(2017/08/22)

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS
The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
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Page/Page column 266

(2016/06/14)

Chemical Properties

Melting Point: 87 °C
Boiling Point: 318.686°C at 760 mmHg
Flash Point:173.868°C
Density: 1.154g/cm³
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.586
PKA: 4.28(at 20℃)
PSA: 32.26000
LogP: 1.15350

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Chemical Properties

Melting Point: 87 °C

Boiling Point: 318.686°C at 760 mmHg

Flash Point:173.868°C

Density: 1.154g/cm³

Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature

Vapor Pressure: 0mmHg at 25°C

Refractive Index: 1.586

PKA: 4.28(at 20℃)

PSA: 32.26000

LogP: 1.15350

Global suppliers and manufacturers of 3418-45-9total 12 suppliers on LookChem

Article Database

3418-45-9

Articles about 3418-45-9Total 3 be found

More Articles about upstream products of 3418-45-9

Chemical Properties

Melting Point: 87 °C

Boiling Point: 318.686°C at 760 mmHg

Flash Point:173.868°C

Density: 1.154g/cm3

Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature

Vapor Pressure: 0mmHg at 25°C

Refractive Index: 1.586

PKA: 4.28(at 20℃)

PSA: 32.26000

LogP: 1.15350

Global suppliers and manufacturers of 3418-45-9total 12 suppliers on LookChem

Density: 1.154g/cm³