Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
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(2013/06/06)
An efficient chiral synthesis of fluoro-containing amino acids: N-benzyloxycarbonyl-2-amino-4,4-difluorobutyric acid methyl ester and its analogs
Fluoro-containing amino acids, N-benzyloxycarbonyl-2-amino-4,4-difluorobutyric acid methyl ester and analogs, were prepared in high enantiomeric excess. Incorporation of 2-amino-4,4-difluoro butyric acid as P1 group provided a potent HCV NS3 protease inhi
Hu, Zilun,Han, Wei
p. 901 - 902
(2008/09/17)
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