34291-03-7

Basic information

• Product Name: butirosin B
• Synonyms: butirosin B;Ambutyrosin B;N1-[(S)-4-Amino-2-hydroxy-1-oxobutyl]-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-5-O-(β-D-ribofuranosyl)-2-deoxy-D-streptamine;Butyrosin b
• CAS NO: 34291-03-7
• Molecular Formula: C₂₁H₄₁N₅O₁₂
• Molecular Weight: 555.57654
• Mol File: 34291-03-7.mol

Chemical Properties

• Boiling Point: 947.4°Cat760mmHg
• Flash Point: 526.8°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.657
• PKA: pKa (water): 5.3, 7.1, 8.6, 9.8(at 25℃)
• CAS DataBase Reference: butirosin B(CAS DataBase Reference)
• NIST Chemistry Reference: butirosin B(34291-03-7)
• EPA Substance Registry System: butirosin B(34291-03-7)

Safety Data

• Hazardous Substances Data: 34291-03-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Butirosin B is used as an antibiotic for treating bacterial infections. Its unique structure allows it to target and inhibit bacterial protein synthesis, leading to the growth inhibition and death of the bacteria.
Used in Research and Development:
Butirosin B is used as a research tool for studying the mechanisms of aminoglycoside antibiotics and their interactions with bacterial ribosomes. This can help in the development of new antibiotics with improved efficacy and reduced resistance.
Used in Veterinary Medicine:
Butirosin B is used as a veterinary drug for treating and preventing bacterial infections in animals, such as livestock and poultry. Its broad-spectrum activity makes it effective against a wide range of bacterial pathogens.
Used in Drug Resistance Studies:
Butirosin B is used in research to understand the mechanisms of antibiotic resistance in bacteria. This knowledge can be applied to develop strategies to combat the growing problem of antibiotic resistance in the medical and veterinary fields.

InChI:InChI=1/C21H41N5O12/c22-2-1-8(28)19(34)26-7-3-6(24)17(37-20-11(25)15(32)13(30)9(4-23)35-20)18(12(7)29)38-21-16(33)14(31)10(5-27)36-21/h6-18,20-21,27-33H,1-5,22-25H2,(H,26,34)/t6-,7+,8-,9+,10+,11+,12-,13+,14+,15+,16+,17+,18+,20+,21-/m0/s1

Upstream product

• 1064665-42-4 γ-L-Glu-butirosin B 

Relevant articles and documents

Combined chemical-enzymatic assembly of aminoglycoside derivatives with N-1-AHB side chain

A series of unprotected pseudo-disaccharides and pseudo-trisaccharides of 2-deoxystreptamine-containing aminoglycosides have been selectively acylated at the N-1 position with the valuable (S)-4-amino-2-hydroxybutanoyl (AHB) pharmacophore by using the recombinant BtrH and BtrG enzymes from butirosin biosynthesis in combination with a synthetic acyl donor. The process was optimized by performing two enzymatic steps in a sequential manner without purification of the intermediate product.

Chemoenzymatic acylation of aminoglycoside antibiotics

The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine- containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate. The Royal Society of Chemistry.