Benzothiazole derivatives with activity as adenosine receptor ligands
The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.
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(2008/06/13)
ELECTROCHEMICAL REDUCTIVE AMINATION. II. AMINATION OF ALIPHATIC ALDEHYDES WITH PRIMARY AMINES
The formation of a secondary amine by the electrolysis of an aqueous solution containing an aldehyde and a primary amine was studied.The formation of the secondary amines passes through the intermediate stage of an aldimine.The highest yield of secondary amine is attained at a molar ratio of primary amine to aldehyde of 1.2:1.As electrode material lead, cadmium, zinc, and copper may be used.As supporting electrolyte a phosphate buffer with a pH close to the pKa of the primary amine is recommended.By the method developed 32 amines with various structures were synthesized.
Smirnov, Yu. D.,Pavlichenko, V. F.,Tomilov, A. P.
p. 374 - 380
(2007/10/02)
CONFIGURATIONAL BIASING OF TERTIARY AMIDE IONOPHORES BY ALKALI METAL CHELATION1,2.
Configurational analysis can be used as a probe for association constants for chelation of amides with alkali metals. Carbon-13 NMR spectroscopy indicates that tertiary amides, each bearing a triethylene oxide substituent at nitrogen, exist as a mixture of E and Z isomers. Addition of alkali metal cation (KSCN) increases the concentration of species with the Z configuration since this configuration can chelate potassium ion. High-field **1H NMR spectra have been used to determine the chelation constants for amides in the presence of KSCN. It has been determined that (a) the carbonyl oxygen is involved in chelation and (b) the number of ether oxygens on the substituent at nitrogen is the significant factor in the chelating ability of these ionophores.
Craine,Greenblatt,Woodson,Hortelano,Raban
p. 7252 - 7255
(2007/10/02)
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