- N-carbamoylated urethane for treating a neuroinflammatory disease
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There is provided a composition for treating a neuroinflammatory disease comprising a N-carbamoylated urethane compound which has an effect of inhibiting the activity of microglia or astrocytes and the production of nitric oxide (NO) and TNF-α, and suppre
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Paragraph 0123
(2018/02/28)
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- NOVEL COMPOUND HAVING ISOXAZOLE CORE AND PHARMACEUTICAL COMPOSITION FOR DIABETES CONTAINING THE SAME MOLECULAR SKELETONS
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The purpose of the present invention is to provide novel compounds having isoxazole by central structure as a PPAR gamma selective ligand, a manufacturing method thereof, and a pharmaceutical composition for treating PPAR gamma-related diseases containing the novel compounds or pharmaceutically acceptable salt thereof. The compounds can be applied to treatment of PPAR gamma-related diseases, especially, diabetes as an effective medicine without side effects which an existing TZD-series diabetes medicine has.
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Paragraph 0077-0080
(2017/08/02)
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- Phenotypic screening to identify small-molecule enhancers for glucose uptake: Target identification and rational optimization of their efficacy
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Small-molecule glucose uptake enhancers targeted to myotubes and adipocytes were developed through a phenotypic screening linked with target identification and rational optimization. The target protein of glucose-uptake enhancers was identified as a nucle
- Koh, Minseob,Park, Jongmin,Koo, Ja Young,Lim, Donghyun,Cha, Mi Young,Jo, Ala,Choi, Jang Hyun,Park, Seung Bum
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supporting information
p. 5102 - 5106
(2014/05/20)
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- Glycine amides as PPARα agonists
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The design, synthesis and pharmacological properties of a novel class of PPARα agonists is described. Compound 2 is a novel, potent and specific glycine amide with oral bioavailability in rodents. The compound is active in vivo and alters plasma lipids in
- Urbahns, Klaus,Woltering, Michael,Nikolic, Susanne,Pernerstorfer, Josef,Bischoff, Hilmar,Dittrich-Wengenroth, Elke,Lustig, Klemens
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scheme or table
p. 3376 - 3379
(2010/08/20)
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- PHENOXYACETIC ACID DERIVATIVES AND DRUGS USING THE SAME
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It is intended to provide a novel compound having an excellent agonism to PPARs α/γ and desirable properties as a drug. An agonist to peroxisome proliferator-activated receptors α/γ which is represented by the general formula (I) (wherein Q represents an optionally substituted benzene ring or pyridine ring; R1 and R2 represent each an optionally substituted phenyl group or a 5- to 6-membered aromatic heterocycle group; X, Y and Z independently represent each C, O, S or N; R3 to R9 represent each a hydrogen atom, a lower alkyl group, etc.; and n is an integer of from 0 to 3.
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Page/Page column 26
(2010/11/26)
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- PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME
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Novel compounds having excellent PPAR α/γ agonist effects and having desirable properties for medicaments are provided. Peroxisome proliferator-activated receptor α/γ agonists of the general formula (I): (wherein Q is an optionally-substituted benzene or
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Page/Page column 13-14
(2010/11/25)
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- PYRAZOLE DERIVATIVES
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A compound represented by the general formula (I), which is useful as a peroxisome proliferator-activated receptor α/γ agonist, a salt of the compound, and a solvate of either. (In the formula, X, Y, and Z each represents nitrogen or carbon; m is an integ
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Page/Page column 40-41
(2010/10/19)
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- Propionic acid derivatives
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The present application relates to novel potent PPAR-alpha-activating compounds for treating, for example, coronary heart disease, and to their preparation.
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