34367-04-9

Basic information

• Product Name: GinsenosideRo
• Synonyms: Chikusetsusaponin 5;ChikusetsusaponinV;PolysciasaponinP3;β-D-Glucopyranosiduronic acid, (3β)-28-(β-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl2-O-β-D-glucopyranosyl-;28-(β-D-Glucopyranosyloxy)-28-oxo-5α-olean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid;28-(β-D-Glucopyranosyloxy)-28-oxoolean-12-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranosiduronic acid;3β-(2-O-β-D-Glucopyranosyl-β-D-glucopyranuronosyloxy)oleana-12-ene-28-oic acid 28-β-D-glucopyranosyl ester;Chikusetusaponin V
• CAS NO: 34367-04-9
• Molecular Formula: C48H76O19
• Molecular Weight: 957.109
• Product Categories: The group of Ginsenosides;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 34367-04-9.mol

Chemical Properties

• Boiling Point: 1018.6 °C at 760 mmHg
• Flash Point: 289.2 °C
• Appearance: /
• Density: 1.14
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• PKA: 2.76±0.70(Predicted)
• CAS DataBase Reference: GinsenosideRo(CAS DataBase Reference)
• NIST Chemistry Reference: GinsenosideRo(34367-04-9)
• EPA Substance Registry System: GinsenosideRo(34367-04-9)

Safety Data

• Hazardous Substances Data: 34367-04-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
Ginsenoside Ro is used as an anti-inflammatory agent for its ability to inhibit LPS-induced release of ROS and NO, as well as iNOS and COX-2 protein expression in murine macrophages. This makes it a potential candidate for treating inflammation-related conditions.
Used in Cardiovascular Applications:
Ginsenoside Ro is used as an antithrombotic agent for its dose-dependent inhibition of human platelet aggregation and thrombin-induced DIC in rats, which could be beneficial in managing and preventing blood clot-related disorders.
Used in Antiviral Applications:
Ginsenoside Ro is used as an antiviral agent for its ability to increase the survival rate of Sendai virus-infected mice when administered at a specific dose, suggesting its potential use in treating viral infections.
Used in Cosmeceutical Applications:
Ginsenoside Ro is used as a hair regrowth stimulator for its ability to stimulate hair regrowth after shaving in a mouse model of slowed hair regrowth, making it a potential ingredient in hair growth promotion products.
Used in Traditional Medicine:
Ginsenoside Ro, being a natural product found in Panax japonicus var. major, is used in traditional medicine for its various health-promoting properties, including its anti-inflammatory, antithrombotic, and antiviral activities.

InChI:InChI=1/C48H76O19/c1-43(2)14-16-48(42(61)67-40-35(58)31(54)29(52)24(20-50)63-40)17-15-46(6)21(22(48)18-43)8-9-26-45(5)12-11-27(44(3,4)25(45)10-13-47(26,46)7)64-41-37(33(56)32(55)36(65-41)38(59)60)66-39-34(57)30(53)28(51)23(19-49)62-39/h8,22-37,39-41,49-58H,9-20H2,1-7H3,(H,59,60)/t22-,23-,24-,25?,26?,27?,28-,29-,30+,31+,32+,33+,34-,35-,36+,37-,39+,40+,41-,45+,46-,47-,48+/m1/s1

Downstream Products

• 97-30-3 methyl D-glucopyranoside 
• 77594-51-5 C₄₂H₆₆O₁₄ 

Relevant articles and documents

Facile Synthesis of Ginsenoside Ro

Two concise synthetic routes, being different in the glycosylation sequence, toward ginsenoside Ro (1) are developed. These syntheses feature the elaboration of the glucuronide residue at a later stage via the TEMPO-mediated selective oxidation and the installation of AZMB as a benzoylic neighboring participating group capable of being selectively removed afterward.