- Synthesis and catalytic activity of porous polymer containing ionic liquid structures
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A novel porous polymer containing ionic liquid (IL) structures was synthesized via quternization and condensation of 4-vinylpyridine and p-xylylene dichloride. The ionic liquid structures were incorporated in the polymeric framework and for this reason bulky IL molecules can hardly block pores and neutralize active sites. The polymer shows a high BET surface area and easily accessible active sites. Catalytically the polymer is very active in Michael additions with averaged yields over 96.0% achieved after short reaction times. The high BET surface, remarkable activity, operational simplicity, wide applicability and improved stability are the key properties of the polymer.
- Li, Junqiao,Lu, Wei,Li, Weifeng,Liang, Xuezheng
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p. 840 - 846
(2016/12/07)
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- Synthesis of a crosslinked polymer with a benzyl(triphenyl)phosphonium ionic liquid moiety and its catalytic activity
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A novel crosslinked polymer with a benzyl(triphenyl)phosphonium ionic liquid moiety was synthesized from triphenylphosphine and p-xylylene dichloride. The bulky IL molecules were inlaid in the polymeric framework, which avoided pore blocking and IL moiety release. The polymer had a high BET surface area and accessible active sites. The polymer was applied to catalyze the aza-Michael additions and gave average yields over 95.0% in several minutes. The polymer had several advantages such as high BET surface area, high activity and high stability, which hold great potential for green chemical processes.
- Liang, Xuezheng
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p. 99448 - 99453
(2015/12/04)
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- Synthesis of a novel ionic liquid with both Lewis and Br?nsted acid sites and its catalytic activities
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The novel ionic liquid with both Lewis and Br?nsted acid sites has been synthesized and its catalytic activities for acetalization and Michael addition were investigated carefully. The novel ionic liquid was stable to water and could be used in aqueous solution. Furthermore, the molar ratio of the Lewis and Br?nsted acid sites could be adjusted according to different reactions. The results showed that the novel ionic liquid was very efficient for the traditional acid-catalyzed reactions with good to excellent yields in short time.
- Liang, Xuezheng,Qi, Chenze
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experimental part
p. 808 - 812
(2012/01/04)
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- Sterically controlled stereoregulation in aldol reactions of 3-aryl-1-alkyl dihydrothiouracils
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Aldol reactions of 3-aryl-1-alkyl dihydrothiouracils were investigated with respect to the orientation of the exocyclic group at N1, electronic effects of the aryl substituent at N3 and the steric demands of the electrophile. The reactions highlight the preference for formation of the anti aldol diastereomer with increasing steric constraints of the reactants. Georg Thieme Verlag Stuttgart · New York.
- Kumar, Varun,Khatik, Gopal L.,Nair, Vipin A.
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scheme or table
p. 2997 - 3001
(2012/01/13)
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- Novel efficient procedure for the conjugate addition of amines to electron deficient alkenes
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The novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes using the novel SO3H functionalized ionic liquid as catalyst. The results showed that the novel catalyst owned high activities for the reactions with excellent yields within several minutes. Various amines and electron deficient alkenes were successfully transformed to the corresponding products in the catalytic system. Operational simplicity, without need of any solvent, low cost of the catalyst used, room temperature, high yields, reusability, excellent chemoselectivity and wide applicability are the key features of this methodology.
- Sun, Xudong,Du, Yijun,Li, Chunqing,Qi, Chenze
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experimental part
p. 653 - 656
(2011/02/16)
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- Highly efficient procedure for the conjugate addition of amines to electron deficient alkenes
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The novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. The results showed that the catalyst was very efficient for the reactions with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity, applicability to large-scale reactions are the key features of this methodology. The article is published in the original.
- Liao, An-Ping,Lan, Ping,Li, Mei,Lan, Li-Hong
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experimental part
p. 225 - 228
(2010/09/04)
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- Lithium perchlorate-induced electrophilic activation: one-pot synthesis of 3-aryl-2-thioxotetrahydropyrimidin-4-one derivatives from aryl isothiocyanates
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A novel methodology for the synthesis of N-substituted-3-aryl-2-thioxotetrahydropyrimidin-4(1H)-one derivatives had been developed by the condensation of aryl isothiocyanates with β-amino esters using lithium perchlorate as a catalyst and triethylamine as a base. This strategy not only overcomes the disadvantages of the reported methods but also provides high yield of the product in short span of time by an easily workable procedure.
- Kumar, Varun,Nair, Vipin A.
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scheme or table
p. 966 - 969
(2010/04/29)
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- ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS
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The present invention provides a compound of formula (I):said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP- 13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP- 13. Finally, the present invention also provides a pharmaceutical composition.
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Page/Page column 76
(2009/10/22)
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- Tandem bis-aza-Michael addition reaction of amines in aqueous medium promoted by polystyrenesulfonic acid
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An efficient and environmentally benign tandem bis-aza-Michael addition of amines catalyzed by polystyrenesulfonic acid (PSSA) is described. This operationally simple high yielding microwave assisted synthetic protocol proceeded in water in the absence of any organic solvent.
- Polshettiwar, Vivek,Varma, Rajender S.
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p. 8735 - 8738
(2008/03/18)
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- Kinetics of Reversible Endothermic Elimination Reactions: β-Amino Carboxylic Esters and Amides
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The kinetics of the elimination reactions of substituted β-amino carboxylic esters and amides, to give amines and the α,β-unsaturated esters and amides, have been studied in several model systems.The reaction was studied by trapping the olefin formed with another nucleophile capable of competing with the amine formed by elimination.The rate constant for elimination of methyl 3-(N-methyl-N-butylamino)propionate, in methanol at room temperature, is 1.8E-6 s-1.The corresponding amide has an elimination rate constant 8.8E-8 s-1.Rate constants for the forward reaction were also measured and combined with the reversion rate constants to yield equilibrium constants for the same two systems.The equilibrium constants for the methyl esters is 2.0E4 L mol-1 and for the amides is 7.3E3 L mol-1.These were confirmed by measurement of the equilibrium concentrations of olefins by 1H NMR spectroscopy.
- Johnson, Mark R.
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p. 833 - 837
(2007/10/02)
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