- Cyclization of 5-amino-1-aryl-1H-pyrazole-4-carbonitriles with β-dicarbonyl compounds
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[Figure not available: see fulltext.] A method has been developed for the preparation of new pyrazolo[3,4-b]pyridines and tetrahydropyrazolo[3,4-b]quinolinones by the reactions of 5-amino-1-aryl-1H-pyrazole-4-carbonitriles with aliphatic and cyclic 1,3-di
- Potapov, Andrei Yu.,Vandyshev, Dmitriy Yu.,Kosheleva, Yevgeniya A.,Polikarchuk, Vladimir A.,Potapov, Mikhail A.,Shikhaliev, Khidmet S.
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p. 207 - 212
(2017/05/19)
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- Heterocyclic synthesis with nitriles: Synthesis of pyrazolopyrimidine and pyrazolopyridine derivatives
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The reaction of N1-substituted-5-amino-4-cyanopyrazoles with malononitrile and diethylmalonate occurs with formation of 6-substituted pyrazolo[3,4-d] pyrimidines, and pyrazolo[3,4-b]pyridines respectively. The structures of the products and conceivable mechanisms are discussed. Copyright Taylor & Francis Group, LLC.
- Salaheldin, Abdellatif M.,Oliveira-Campos, Ana M. F.,Rodrigues, Ligia M.
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experimental part
p. 1186 - 1195
(2009/09/30)
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- Pyrazolo-pyridine derivatives as ligands for gaba receptors
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A class of substituted and/or ring-fused pyrazolo[3,4-b]pyridine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent on the pyrazole nitrogen atom adjacent the pyridine nucleus, and an optionally substituted cycloalkyl-alkoxy, aryl-alkoxy or heteroaryl-alkoxy substituent on the carbon atom adjacent the pyridine ring nitrogen atom, are selective ligands for GABAA receptors, in particular having high affinity for the β2 and/or β3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse neurological disorders, including anxiety and convulsions.
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