- Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: Synthesis of natural products and drugs
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A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilised to synthesize various quinazolinone natural products and drugs.
- Ghosh, Suman Kr,Nagarajan, Rajagopal
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p. 27378 - 27387
(2016/04/04)
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- CuI/l-proline-catalyzed intramolecular aryl amination: An efficient route for the synthesis of 1,4-benzodiazepinones
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An effective protocol for the synthesis of potentially bioactive benzo[e]chromeno[6,5-b][1,4]diazepine-3,8(7H,13H)-dione and dibenzo[b,e][1,4] diazepin-11(10H)-one derivatives in good to excellent yields has been achieved by CuI/l-Proline catalyzed coupling reaction as the key step. The methodology offers clean reaction conditions and easy isolation of the products in 61-92% yields.
- Majumdar,Ganai, Sintu
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scheme or table
p. 1881 - 1887
(2011/10/05)
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