Synthesis of Halogenated Pyridines via the CuCl-Catalyzed Addition of Polyhaloacetonitriles to Olefins
Halogenated acetonitriles add smoothly to acrolein, methacrolein, and methacrolein dimethyl acetal in the presence of a catalytic amount of CuCl and triphenylphosphine, tri-n-butylphosphine, or triethylamine to give halogenated difunctional adducts.The adducts have been cyclized in high yields under acidic conditions to halogenated pyridines.
Pews, R. Garth,Lysenko, Zenon
p. 5115 - 5119
(2007/10/02)
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