2,3-Disubstituted acrylamides as potent glucokinase activators
The phenylacetamide 1 represents the archtypical glucokinase activator (GKA) in which only the R-isomer is active. In order to probe whether the chiral center could be replaced, we prepared a series of olefins 2 and show in the present work that these com
Sidduri, Achyutharao,Grimsby, Joseph S.,Corbett, Wendy L.,Sarabu, Ramakanth,Grippo, Joseph F.,Lou, Jianping,Kester, Robert F.,Dvorozniak, Mark,Marcus, Linda,Spence, Cheryl,Racha, Jagdish K.,Moore, David J.
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p. 5673 - 5676
(2010/11/17)
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