346725-77-7Relevant articles and documents
Direct Amidation of N-Boc- and N-Cbz-Protected Amines via Rhodium-Catalyzed Coupling of Arylboroxines and Carbamates
Lim, Diane S. W.,Lew, Tedrick T. S.,Zhang, Yugen
, p. 6054 - 6057 (2016/01/09)
N-Boc- and N-Cbz-protected amines are directly converted into amides by a novel rhodium-catalyzed coupling of arylboroxines and carbamates, replacing the traditional two-step deprotection-condensation sequence. Both protected anilines and aliphatic amines are efficiently transformed into a wide variety of secondary benzamides, including sterically hindered and electron-deficient amides, as well as in the presence of acid-labile and reducible functional groups.
Copper(i)-catalyzed amidation reaction of organoboronic esters and isocyanates
Salim Lew, Tedrick Thomas,Wen Lim, Diane Shu,Zhang, Yugen
, p. 5140 - 5143 (2015/12/05)
A simple and efficient methodology for the preparation of amides from easily available organoboronic esters and isocyanates has been accomplished using a ligand-free copper(i) catalyst. The reaction system demonstrated a broad substrate scope and provided convenient access to a wide variety of secondary amides.
Pharmaceutical compositions containing phenylamides
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, (2008/06/13)
Pharmaceutical compositions for inhibiting the aggregation of erthyrocytes or thrombocytes which include phenylamides which conform to the formula: STR1 with R1-6, X, A and B being as defined. Processes for the preparation of novel phenylamides