NEW GLYCOLIPIDS AND USE THEREOF AS SK3 ION CHANNEL MODULATORS
The present invention relates to new glycolipids derivatives of Formula (I) and their use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels. The present invention further relates to pharmaceutical compositions comprising compounds of Formula (I) for use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels.
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Page/Page column 36; 41
(2022/01/24)
Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect
The modulation of SK3 ion channels can be efficiently and selectively achieved by using the amphiphilic compound Ohmline (a glyco-glycero-ether-lipid). We report herein a series of Ohmline analogues featuring the replacement of one ether function by a thi
Sevrain, Charlotte M.,Fontaine, Delphine,Bauduin, Alicia,Guéguinou, Maxime,Zhang, Bei Li,Chant?me, Aurélie,Mahéo, Karine,Pasqualin, C?me,Maupoil, Véronique,Couthon, Hélène,Vandier, Christophe,Jaffrès, Paul-Alain
p. 2753 - 2766
(2021/04/07)
Macrocyclic kinase inhibitors
Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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Page/Page column 79
(2010/02/14)
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