A one-pot oxidation-imine formation-reduction route from alcohols to amines using manganese dioxide-sodium borohydride: The synthesis of naftifine
A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine.
Kanno, Hisashi,Taylor, Richard J.K.
p. 7337 - 7340
(2007/10/03)
In Situ Oxidation-Imine Formation-Reduction Routes from Alcohols to Amines
(matrix presented) Manganese dioxide is employed as an in situ oxidant for the one-pot conversion of alcohols into imines. In combination with polymer-supported cyanoborohydride (PSCBH), a one-pot oxidation-imine formation-reduction sequence is reported. This procedure enables alcohols to be converted directly into both secondary and tertiary amines.
Blackburn, Leonie,Taylor, Richard J. K.
p. 1637 - 1639
(2007/10/03)
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