- Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation
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Quinazoline derivatives represented by the formula SPC1 Wherein R1 and R2 are individually a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, a lower alkylthio group or a lower alkylsulfonyl group; R3 is a hydrogen atom, a lower alkyl group, a lower cycloalkyl group, a napthyl group, a furyl group or a thienyl group; R4 is a lower cycloalkyl group or a trihalomethyl group; and n is an integer of 1 to 3, are novel compounds and have excellent pharmacological properties, particularly as anti-inflammatory and analgesic effects with low toxicity. They can be prepared by treating with ammonia a trihaloacetamidophenylketone derivative of the formula, SPC2 Wherein R1, R2 and R3 are as defined above; R is a hydrogen atom or a group of the formula --Cn H2n --R4 ; and X is a halogen atom.
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