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AcetaMide, 2,2,2-trifluoro-N-(1-Methylethyl)-, also known as α,α,α-trifluoro-N-isopropylacetamide, is a chemical compound with the molecular formula C5H9F3NO. It is a colorless liquid with a molecular weight of 163.13 g/mol. AcetaMide, 2,2,2-trifluoro-N-(1-Methylethyl)- is characterized by the presence of a trifluoromethyl group, an isopropylmethyl group, and an amide functional group. It is used as a reagent in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. Due to its unique properties, such as increased lipophilicity and metabolic stability, it can enhance the bioavailability and pharmacokinetics of the target compounds. The compound is also known for its potential applications in the development of new materials and as a building block in the synthesis of more complex molecules.

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  • 348-76-5 Structure
  • Basic information

    1. Product Name: AcetaMide, 2,2,2-trifluoro-N-(1-Methylethyl)-
    2. Synonyms: AcetaMide, 2,2,2-trifluoro-N-(1-Methylethyl)-
    3. CAS NO:348-76-5
    4. Molecular Formula: C5H8F3NO
    5. Molecular Weight: 155.1183296
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 348-76-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: AcetaMide, 2,2,2-trifluoro-N-(1-Methylethyl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: AcetaMide, 2,2,2-trifluoro-N-(1-Methylethyl)-(348-76-5)
    11. EPA Substance Registry System: AcetaMide, 2,2,2-trifluoro-N-(1-Methylethyl)-(348-76-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 348-76-5(Hazardous Substances Data)

348-76-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 348-76-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 348-76:
(5*3)+(4*4)+(3*8)+(2*7)+(1*6)=75
75 % 10 = 5
So 348-76-5 is a valid CAS Registry Number.

348-76-5Relevant articles and documents

Towards the Development of Frustrated Lewis Pair (FLP) Catalyzed Hydrogenations of Tertiary and Secondary Carboxylic Amides

K?ring, Laura,Paradies, Jan,Sitte, Nikolai A.

supporting information, p. 1287 - 1300 (2022/01/20)

The development of the frustrated Lewis pair catalyzed hydrogenation of tertiary and secondary amides is reviewed. Detailed insight into our strategies in order to overcome challenges during the reaction development process is provided. Furthermore, the d

Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

Augurusa, Alessandra,Mehta, Meera,Perez, Manuel,Zhu, Jiangtao,Stephan, Douglas W.

supporting information, p. 12195 - 12198 (2016/10/21)

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.

Convenient one-pot synthesis of N-substituted 3-trifluoroacetyl pyrroles

Zanatta, Nilo,Wouters, Ana D.,Fantinel, Leonardo,Da Silva, Fabio M.,Barichello, Rosemário,Da Silva, Pedro E. A.,Ramos, Daniela F.,Bonacorso, Helio G.,Martins, Marcos A. P.

experimental part, p. 755 - 758 (2009/07/18)

A new one-pot strategy for the synthesis of a series of new N-substituted 3-trifluoroacetyl pyrroles is presented. These compounds were obtained by the reaction of 3-trifluoroacetyl-4,5-dihydrofuran with primary amines, which generated 1,1,1-trifluoro-3-(2-hydroxyethyl)-4-alkylaminobut-3-en-2-one intermediates. In most cases these intermediates were not stable enough to be isolated. Thus, in the same reaction vessel they were directly submitted to oxidation with PCC (Corey's reagent) to furnish 1,1,1-trifluoro-3-(2-ethanal)-4- alkylaminobut-3-en-2-ones, which under reflux underwent intramolecular cyclization to give the desired N-substituted 3-trifluoroacetyl pyrroles, in moderate yields. All of these pyrroles were tested against pan-susceptible Mycobacterium tuberculosis H37Rv and clinical isolates INH- and RMP-resistant strain and some of these compounds showed significant in vitro antimicrobial activity. Georg Thieme Verlag Stuttgart.

BIPHENYL DERIVATIVES USEFUL AS LIGANDS THAT ACTIVATE THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS

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Page/Page column 25, (2010/02/12)

The present invention relates to novel compounds corresponding to the general formula (I) below: to compositions containing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic

Conformations and Vibrational Dynamics of Six Monoalkyltrifluoroacetamides. Low-Resolution Microwave and Gas-Phase NMR Spectroscopic Studies

True, Nancy S.,Ross, Brian D.

, p. 3216 - 3220 (2007/10/02)

Low resolution microwave spectra of six N-alkyltrifluoroacetamides (F3C(O)NHR; r = CH3, C2H5, i-C3H7, n-C3H7, i-C4H9, t-C4H9) display band series consistent with a single species having the R group oriented syn to the carbonyl moiety. 5JH-F coupling constats observed in gas- and liquid-phase NMR spectra of N-methyltrifluoroacetamide confirm this assignment.For each molecule the observed rotational constats, anomalously broad microwave bandwidths, and absence of resolvable fine structure are consistent with predicted effects of rapid intramolecular vibrational redistribution (IVR).Sufficient state density for IVR in these molecules occurs at low internal energies.

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