An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P)
A small, focused combinatorial library encompassing all possible permutations of acyl branched alkyl chains - small and large, saturated and unsaturated - was generated from the active diacylglycerol enantiomer (S-DAG) to help identify the analogue with t