- DRUGS WITH ANTICHOLESTATIC ACTIVITY
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New compounds belonging to the structural formula (I) are described. in which R1, R2, A, Y and X are specified in the description, useful in the treatment of cholestasis and substantially devoid of antibacterial activity. The synthesis process of said compounds, the pharmaceutical compositions containing them and their use in therapy are also described.
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Page/Page column 6
(2010/07/08)
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- NEW DRUGS WITH ANTICHOLESTATIC ACTIVITY
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New compounds belonging to the structural formula (I) are described. formula (I) in which R1, R2, A, Y and X are specified in the description, useful in the treatment of cholestasis and substantially devoid of antibacterial activity. The synthesis process of said compounds, the pharmaceutical compositions containing them and their use in therapy are also described.
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Page/Page column 16
(2009/03/07)
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- Benzamide derivatives
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A compound of the formula (I), and pharmaceutically acceptable salts thereof: STR1 wherein: R1 is a C1-6 alkoxy group; R2 and R3 are the same or different and are hydrogen, halogen, CF3, hydroxy, C1-6 alkoxy, C2-7 acyl, amino, amino substituted by one or two C1-6 alkyl groups, C2-10 acyl amino, aminosulphone, aminosulphone substituted by one or two C1-6 alkyl groups, C1-6 alkyl sulphone or nitro groups; and A is a C2-4 alkylene group; R5 and R6 are joined so that they form with the --N--A--N-- group to which they are attached, a 6, 7 or 8 membered heterocyclic ring; R7 is a C1-6 alkyl group, or an aryl --C1-6 akyl group in which the alkyl moiety is optionally substituted by a C1-6 alkyl or aryl group; have useful pharmacological activity, such as the ability to regulate the gastrointestinal function and to treat emesis.
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