349627-22-1Relevant articles and documents
Potent non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex
Sun, Aiming,Yoon, Jeong-Joong,Yin, Yan,Prussia, Andrew,Yang, Yutao,Min, Jaeki,Plemper, Richard K.,Snyder, James P.
scheme or table, p. 3731 - 3741 (2009/04/10)
Measles virus (MV) is one of the most infectious pathogens known. In spite of the existence of a vaccine, approximately 350000 deaths/year result from MV or associated complications. Antimeasles compounds could conceivably diminish these statistics and pr
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation
Sun, Aiming,Chandrakumar, Nizal,Yoon, Jeong-Joong,Plemper, Richard K.,Snyder, James P.
, p. 5199 - 5203 (2008/02/12)
High-throughput screening has identified 1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide 16677 as a novel and potent (IC50 = 35-145 nM) inhibitor against multiple primary isolates of diverse measles vir