34970-69-9

Basic information

• Product Name: BURIMAMIDE OXALATE
• Synonyms: BURIMAMIDE OXALATE;Burimamide;N-[4-(1H-Imidazol-4-yl)butyl]-N'-methylthiourea;N-[4-(1H-Imidazol-4-yl)butyl]-N'-methylthioureaoxalate
• CAS NO: 34970-69-9
• Molecular Formula: C₉H₁₆N₄S
• Molecular Weight: 212.32
• Mol File: 34970-69-9.mol

Chemical Properties

• Boiling Point: 426.6°Cat760mmHg
• Flash Point: 211.8°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 1.74E-07mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Desiccate at +4°C
• PKA: pKa 7.5 (Uncertain)
• CAS DataBase Reference: BURIMAMIDE OXALATE(CAS DataBase Reference)
• NIST Chemistry Reference: BURIMAMIDE OXALATE(34970-69-9)
• EPA Substance Registry System: BURIMAMIDE OXALATE(34970-69-9)

Safety Data

• Hazardous Substances Data: 34970-69-9(Hazardous Substances Data)

Usage

Biological Activity

Histamine H 3 /H 2 receptor antagonist (K i values are 0.07, 7.8 and 290 μ M for H 3 , H 2 and H 1 receptors respectively). Displays partial agonist activity in SK-N-MC cells. Produces antinociceptive effects following intraventricular administration (ED 50 = 183 nmol/mouse in hot-plate test).

InChI:InChI=1/C9H16N4S/c1-10-9(14)12-5-3-2-4-8-6-11-7-13-8/h6-7H,2-5H2,1H3,(H,11,13)(H2,10,12,14)

Upstream product

• 556-61-6 methyl thioisocyanate 

Relevant articles and documents

New analogs of burimamide as potent and selective histamine H3 receptor antagonists: The effect of chain length variation of the alkyl spacer and modifications of the N-thiourea substituent

Burimamide was one of the first compounds reported to antagonize the activation of the histamine H3 receptor by histamine. We have prepared a large series of burimamide analogs by variation of the alkyl spacer length of burimamide from two methylene groups to six methylene groups and also by replacement of the N-methyl group with other alkyl and aryl groups. All analogs are reversible, competitive H3 antagonists as determined on the guinea pig intestine. Elongation of the alkyl chain from an ethylene chain to a hexylene chain results in an increase of the H3 antagonistic activity. The H3 selective pentylene and hexylene analogs of burimamide are about 10 times more potent than burimamide. The N-thiourea substituents, however, have no beneficial influence on the affinity.