- An efficient method for the synthesis of quinoxaline derivatives catalyzed by titanium silicate-1
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Abstract: A series of quinoxaline derivatives were efficiently synthesized by convenient and simple procedure in excellent yields using 1 wt.% of titanium silicate (TS-1) catalyzed reaction of 1,2-diamines and 1,2-diketones in methanol at room temperature
- Chandrachood, Pranav S.,Jadhav, Amol R.,Garud, Dinesh R.,Deshpande, Nirmala R.,Puranik, Vedavati G.,Kashalkar, Rajashree V.
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p. 5219 - 5230
(2020/09/18)
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- Aqueous hydrofluoric acid catalyzed facile synthesis of 2,3,6-substituted quinoxalines
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A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines in excellent yield is developed from θ-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures.
- Chandra Shekhar,Ravi Kumar,Sathaiah,Raju,Srinivas,Shanthan Rao,Narsaiah
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p. 1504 - 1508
(2015/04/27)
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- An efficient and recyclable nanoparticle-supported cobalt catalyst for quinoxaline synthesis
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The syntheses of quinoxalines derived from 1,2-diamine and 1,2-dicarbonyl compounds under mild reaction conditions was carried out using a nanoparticle-supported cobalt catalyst. The supported nanocatalyst exhibited excellent activity and stability and it
- Rajabi, Fatemeh,Alves, Diego,Luque, Rafael
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p. 20709 - 20718
(2015/12/23)
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- Design, synthesis and biological evaluation of novel fluorinated heterocyclic hybrid molecules based on triazole & quinoxaline scaffolds lead to highly potent antimalarials and antibacterials
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A series of novel fluorinated heterocyclic hybrid molecules based on triazole & quinoxaline scaffold were designed, synthesized and evaluated for inhibition of Plasmodium falciparum, a virulent human malaria parasite. Mono and bis triazole tagged quinoxal
- Chandra Shekhar, Adimulam,Venkat Lingaiah, Boddupally Pedda,Shanthan Rao, Pamulaparthy,Narsaiah, Banda,Aparna Devi, Allanki,Sijwali, Puran Singh
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p. 393 - 407
(2015/06/22)
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- Yb modified NaY zeolite: A recyclable and efficient catalyst for quinoxaline synthesis
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In this study, Yb immobilized NaY zeolite catalyst (Yb/NaY) was obtained by a hydrothermal method and characterized by XRD, BET, FT-IR, ICP-AES, and NH3-TPD. The catalyst displayed good catalytic activity when applied to the synthesis of quinoxalines via condensation of α-hydroxyketones with 1,2-diamines, and could be reused several times without any loss of catalytic activity.
- Fan, Li-Yan,Wei, Lin,Hua, Wen-Jun,Li, Xiang-Xiong
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supporting information
p. 1203 - 1206
(2014/08/18)
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- Emergence of pyrido quinoxalines as new family of antimalarial agents
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A series of novel N-alkyl dihydro pyrido quinoxaline derivatives were synthesized using Gould-Jacobs reaction and evaluated their antimalarial activity in vitro against chloroquine sensitive (3D7) and drug resistant (Dd2) strains of Plasmodium falciparum.
- Chandra Shekhar,Shanthan Rao,Narsaiah,Allanki, Aparna Devi,Sijwali, Puran Singh
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p. 280 - 287
(2014/04/03)
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- A green and efficient protocol for the synthesis of quinoxaline, benzoxazole and benzimidazole derivatives using heteropolyanion-based ionic liquids: As a recyclable solid catalyst
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In this paper, we introduce two nonconventional ionic liquid compounds which are composed of propane sulfonate functionalized organic cations and heteropolyanions as green solid acid catalysts for the highly efficient and green synthesis of 2,3-disubstitutedquinoxaline derivatives. These ionic liquids are in the solid state at room temperature and the synthesis is carried out via the one-pot condensation reaction of various o-phenylenediamine with 1,2-diketone derivatives. Benzoxazole and benzimidazole derivatives were also synthesized by these novel catalysts via the one-pot condensation from reaction orthoester with o-aminophenol (synthesis of benzoxazole derivatives) and ophenylenediamine (synthesis of benzimidazole derivatives). All experiments successfully resulted in the desired products. The described novel synthesis method has several advantages of safety, mild condition, high yields, short reaction times, simplicity and easy workup compared to the traditional method of synthesis.
- Vahdat, Seyed Mohammad,Baghery, Saeed
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p. 618 - 627
(2013/09/12)
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- A novel and simple synthesis of some new and known dibenzo phenazine and quinoxaline derivatives using lead dichloride
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A simple method for the synthesis of phenazine and quinoxaline derivatives have been developed via a reaction of o-phenylenediamines and 1,2-dicarbonyl compounds or aryl glyoxals in the presence of lead dichloride in ethanol at room temperature. This meth
- Karami, Bahador,Khodabakhshi, Saeed
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p. 1655 - 1658
(2013/09/24)
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- Nano-BF3·SiO2: A reusable and eco-friendly catalyst for synthesis of quinoxalines
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2,3-Disubstituted quinoxalines were synthesized via condensation of α-diketones and 1,2-phenylenediamines. Nano-BF3·SiO 2 as a "green" and reusable solid acid was used as the catalyst for the synthesis of quinoxalines. The reaction was carried out at room temperature under sonication with high to excellent yields.
- Mirjalili,Bamoniri,Akbari
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experimental part
p. 487 - 491
(2012/01/13)
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- Fe/Al-MCM-41: An efficient and reusable catalyst for the synthesis of quinoxaline derivatives
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Fe/Al-MCM-41was found to be an effective catalyst for the synthesis of quinoxaline derivatives from the condensation of the 1,2-diamines and 1,2-dicarbonyl compounds in good yields. The catalyst is recyclable and reusable.
- Heravi, Majid M.,Hosseini, Mariam,Oskooie, Hossein A.,Baghernejad, Bita
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experimental part
p. 235 - 239
(2011/06/26)
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- Nano-TiO2: An eco-friendly alternative for the synthesis of quinoxalines
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Nano-TiO2 as an eco-friendly and efficient nanocatalyst was applied for quinoxaline preparation with improved yield. In this protocol, diketones and 1,2-diamines were condensed in the presence of catalyst at room temperature.
- Mirjalili, Bi Bi Fatemeh,Akbari, Ali
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experimental part
p. 753 - 756
(2012/01/05)
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- Niobium pentachloride as a highly efficient catalyst for the synthesis of quinoxaline derivatives
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Niobium pentachloride is found to be an efficient catalyst for the synthesis of quinoxaline derivatives via the condensation of aromatic 1,2-dicarbonyl compounds (or unsymmetrical 1,2-diketones or α-hydroxy ketones) with 1,2-diamines. All the reactions were performed at room temperature while using acetonitrile as solvent. The present methodology offers several advantages such as excellent yields, short reaction time and environmentally benign milder reaction conditions.
- Kidwai, Mazaahir,Mishra, Neeraj Kumar,Bhatnagar, Divya,Jahan, Anwar
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experimental part
p. 5051 - 5054
(2012/07/03)
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- Wells-Dawson type heteropolyacid catalyzed synthesis of quinoxaline derivatives at room temperature
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Wells-Dawson heteropolyacid (H6P2W18O 62 ? 24H2O) was used as an effective catalyst for the synthesis of biologically active quinoxaline derivatives from the condensation of o-phenylenediamines with 1,2-dicarbonyl compounds at room temperature in excellent yields. Springer-Verlag 2007.
- Heravi, Majid M.,Bakhtiari, Khadijeh,Bamoharram, Fatemeh F.,Tehrani, Maryam H.
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p. 465 - 467
(2008/02/02)
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- Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors
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A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay a
- Zhang, Li,Qiu, Beiying,Xiong, Bing,Li, Xin,Li, Jingya,Wang, Xin,Li, Jia,Shen, Jingkang
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p. 2118 - 2122
(2008/02/01)
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- Synthesis and reactivity of difluoroaromatic compounds containing heterocyclic central groups
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The reaction of trichloroacetaldehyde with fluorobenzene, followed by a series of transformations, gave 4-fluorobenzil and 4,4′-difluorobenzil which were used in the synthesis of new difluoroaromatic compounds with a heterocyclic central group. The 1H, 13C, and 19F NMR spectra of the newly synthesized difluoroaromatic compounds were studied. The charge densities on the carbon atoms attached to fluorine were calculated in terms of the PM3 and AM1 semiempirical approximations. A correlation was found between the charge on C(F) and the corresponding 13C and 19F chemical shifts. Using this correlation, the reactivity of difluoroaromatic compounds in nucleophilic substitution reactions was estimated.
- Keshtov,Keshtova,Begretov,Tkhakakhov
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p. 1476 - 1480
(2007/10/03)
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