351003-62-8

Basic information

• Product Name: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE
• Synonyms: SALOR-INT L301078-1EA;4-BROMO-2-(TRIFLUOROMETHYL)BENZENESULPHONAMIDE;4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE;4-BROMO-2-(TRIFLLUOROMETHYL)BENZENESULPHONAMIDE;4-Bromo-6-trifluoromethylbenzenesulfonamide;4-Bromo-6-trifluoromethylbenzene;5-Bromo-2-sulphamoylbenzotrifluoride, 2-(Aminosulphonyl)-5-bromobenzotrifluoride
• CAS NO: 351003-62-8
• Molecular Formula: C₇H₅BrF₃NO₂S
• Molecular Weight: 304.08
• Mol File: 351003-62-8.mol

Chemical Properties

• Melting Point: 157-158°C
• Boiling Point: 346.6 °C at 760 mmHg
• Flash Point: 163.4 °C
• Appearance: /
• Density: 1.809 g/cm³
• Vapor Pressure: 5.71E-05mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE(351003-62-8)
• EPA Substance Registry System: 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE(351003-62-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 351003-62-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE is used as a pharmaceutical intermediate for the synthesis of various pharmaceuticals. It plays a crucial role in the development of new drugs and contributes to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical industry, 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE is utilized as a building block in the synthesis of agrochemicals. It aids in the development of new pesticides and other agricultural chemicals, enhancing crop protection and productivity.
Used in Organic Synthesis:
4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE is employed as a reagent in organic synthesis. It is instrumental in the creation of various organic compounds, contributing to the advancement of chemical research and the development of new materials and products.
Used in Chemical Research:
As a reagent in chemical research, 4-BROMO-2-(TRIFLUOROMETHYL)BENZENE SULFONAMIDE is used to study chemical reactions and mechanisms. It helps researchers gain insights into the behavior of different chemical compounds and contributes to the understanding of chemical processes.

InChI:InChI=1/C7H5BrF3NO2S/c8-4-1-2-6(15(12,13)14)5(3-4)7(9,10)11/h1-3H,(H2,12,13,14)

Upstream product

• 176225-10-8 4-bromo-2-(trifluoromethyl)benzene-1-sulfonyl chloride 

Downstream Products

• 1034925-43-3 4-(2,4-dichloro-phenylamino)-2-trifluoromethyl-benzenesulfonamide 

Relevant articles and documents

PHOSPHODIESTERASE INHIBITORS AND USE

The invention provides compounds that may inhibits to ENPP1, and are accordingly useful for treatment disorders related to ENPP1. The invention further provides pharmaceutical compositions containing these compounds and methods of using these compounds to treat or prevent disorders related to ENPP1.

ARYL SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR

In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; trea

SUBSTITUTED BIPHENYL DERIVATIVE

The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C6-C10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C1-C6 alkyl)amino group, a di-(C1-C6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C1-C6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R3 represents a C1-C6 alkyl group, and so on; and R4 represents a C1-C6 alkyl group, and so on.

Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping

Virtual screening against a pCDK2/cyclin A crystal structure led to the identification of a potent and novel CDK2 inhibitor, which exhibited an unusual mode of interaction with the kinase binding motif. With the aid of X-ray crystallography and modelling,