351015-76-4Relevant articles and documents
Synthesis of 1-Substituted Indole-3-carboxaldehydes Related to Acyclic Nucleosides and Their Condensed Pyrenyl Derivatives
Zahran, Magdy A.,Afify, Hanan M.,Pedersen, Erik B.,Nielsen, Claus
, p. 101 - 114 (2007/10/03)
Indole-3-carboxaldehyde was N-alkylated to give the corresponding acyclic nucleosides 3a-h which were condensed with 1-pyrenamine and 1-acetylpyrene to give 5a,c,e-g and 7b-d,e,g, respectively. The Schiff's bases 5a and 5e with 2-hydroxyethyl and methylthiomethyl N-1-substituents were found moderate active against HIV-1.