Synthesis of Acylborons by Ozonolysis of Alkenylboronates: Preparation of an Enantioenriched Amino Acid Acylboronate
A concise synthesis of acylborons was achieved by ozonolysis of alkenyl MIDA (N-methyliminodiacetic acid) boronates. This reaction exhibits excellent functional-group tolerance and is applicable to various acyl MIDA boronates and potassium acyltriflurobor
Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing
Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
Bernard, Sylvain,Defoy, Daniel,Dory, Yves L.,Klarskov, Klaus
supporting information; experimental part
p. 6127 - 6130
(2010/06/13)
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