351062-08-3

Basic information

• Product Name: Necrostatin-7 (Nec-7)
• Synonyms: Necrostatin-7 (Nec-7);5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone;Necrostatin-7;Nec-7;(5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one
• CAS NO: 351062-08-3
• Molecular Formula: C₁₆H₁₀FN₅OS₂
• Molecular Weight: 371.4119032
• Mol File: 351062-08-3.mol

Chemical Properties

• Boiling Point: 613.4±65.0 °C(Predicted)
• Appearance: yellow to tan/
• Density: 1.63±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO: >10mg/mL (with warming)
• PKA: 11.56±0.50(Predicted)
• CAS DataBase Reference: Necrostatin-7 (Nec-7)(CAS DataBase Reference)
• NIST Chemistry Reference: Necrostatin-7 (Nec-7)(351062-08-3)
• EPA Substance Registry System: Necrostatin-7 (Nec-7)(351062-08-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 351062-08-3(Hazardous Substances Data)

Upstream product

• 306936-57-2 3-(4-fluorophenyl)-1H-pyrazole-4-carbaldehyde 
• 309727-45-5 C₆H₅N₃OS₂ 
• 5448-49-7 2-chloro-N-(1,3-thiazol-2-yl)acetamide 
• 326-33-0 4-fluoroacetophenone semicarbazone 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Relevant articles and documents

UNSATURATED HETEROCYCLIC INHIBITORS OF NECROPTOSIS

The invention features new small molecule inhibitors of necroptosis. The compounds of the invention are described by Formulas (I) and (II). The invention also features pharmaceutical compositions that include compounds of Formula (I) and (II). The compounds and compositions of the invention are also featured in kits and in methods of treatment of conditions that include neurodegenerative diseases, ischemic brain and heart injuries, and head trauma.

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.