351184-42-4

Basic information

• Product Name: N-FMOC-4-PIPERIDINOL
• Synonyms: FMOC-4-HYDROXYPIPERIDINE;N-FMOC-4-PIPERIDINOL;4-Hydroxy-1-piperidinecarboxylic acid 9H-fluoren-9-ylmethyl ester
• CAS NO: 351184-42-4
• Molecular Formula: C20H21NO3
• Molecular Weight: 323.39
• Product Categories: pharmacetical
• Mol File: 351184-42-4.mol

Chemical Properties

• Boiling Point: 510.7 °C at 760 mmHg
• Flash Point: 262.7 °C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 2.97E-11mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: 2-8°C
• PKA: 14.77±0.20(Predicted)
• CAS DataBase Reference: N-FMOC-4-PIPERIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-FMOC-4-PIPERIDINOL(351184-42-4)
• EPA Substance Registry System: N-FMOC-4-PIPERIDINOL(351184-42-4)

Safety Data

• Hazardous Substances Data: 351184-42-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
N-Fmoc-4-piperidinol is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its reactivity and functional group transformations make it a valuable component in the development of new drugs and medicinal compounds.
Used in Organic Synthesis:
In the field of organic synthesis, N-Fmoc-4-piperidinol is utilized as a key intermediate. Its ability to participate in various chemical reactions allows for the creation of a wide range of organic compounds, contributing to the advancement of chemical research and the development of novel materials.
Used in Fine Chemicals Preparation:
N-Fmoc-4-piperidinol plays a crucial role in the preparation of fine chemicals, which are high-purity chemicals used in various industries, including pharmaceuticals, agriculture, and fragrances. Its presence as an intermediate aids in the synthesis of these high-quality chemicals, ensuring their purity and effectiveness in their respective applications.

InChI:InChI=1/C20H21NO3/c22-14-9-11-21(12-10-14)20(23)24-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,14,19,22H,9-13H2

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 204376-55-6 9H-fluoren-9-ylmethyl 4-oxo-1-piperidinecarboxylate 
• 178601-16-6 {1-[(S)-2-(4-Cyano-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid tert-butyl ester 
• 178740-38-0 (1-{2-[4-(N-hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid 
• 172927-65-0 sibrafiban 
• 170096-59-0 (1-{2-[4-(N-hydroxycarbamimidoyl)-benzoylamino]-propionyl}-piperidin-4-yloxy)-acetic acid tert-butyl ester 
• 1619923-56-6 (R)-1-(3-amino-4-(phenylthio)butyl)piperidin-4-yl di-tert-butyl phosphate 

Relevant articles and documents

Alcohols immobilization onto 2-chlorotritylchloride resin under microwave irradiation

The immobilization of alcohols onto 2-chlorotritylchloride resin using microwave irradiation was studied. Three different Fmoc-aminoalcohols were tested: the phenol-like Fmoc-tyramine, the primary alcohol Fmoc-ethanolamine, and the secondary alcohol Fmoc-

Oligospiroketals as novel molecular rods

A modular approach for the synthesis of molecular rods based on oligospiroketals has been developed. The strategy relies on different terminal and intermediate segments, which are joined by ketal formation between ketones and diols. For this purpose it was necessary to develop a new ketalization method to circumvent some problems related with the established methods. The terminal segments are either derived from 4-piperidinone or from 4-oxocyclohexane carboxylic acid whereas the intermediate segments rest on pentaerythritol and cyclohexane-1,4-dione. A series of trispiro (14-18), hexaspiro (19) and nonaspiro (20) compounds have been prepared and characterized. From these we realized that it is imperative to use solubility enhancing groups if more than seven rings are joined.

Mio- and Dio-Fmoc - Two modified Fmoc protecting groups promoting solubility

Two novel Fmoc-derived protecting groups, Mio-Fmoc and Dio-Fmoc, were developed, which cause dramatically enhanced solubility of the corresponding derivatives in most organic solvents. Furthermore, the suitability of these groups in solid-phase peptide synthesis was highlighted. Georg Thieme Verlag Stuttgart.

Concise synthesis of sibrafiban and lamifiban, two non-peptide fibrinogen receptor (GP IIb/IIIa) antagonists

The total synthesis of the non-peptide fibrinogen receptor antagonists, sibrafiban (1) (Ro 48-3657) and lamifiban (2) (Ro 44-9883), is described. Both contain 4-hydroxypiperidine unit and the same solid-phase synthesis method was used as a key step. Conne