New quinoline-based heterocycles as anticancer agents targeting Bcl-2
The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (ABT-19
Hamdy, Rania,Elseginy, Samia A.,Ziedan, Noha I.,Jones, Arwyn T.,Westwell, Andrew D.
(2019/04/05)
Synthesis, molecular docking and anti-inflammatory screening of novel quinoline incorporated pyrazole derivatives using the Pfitzinger reaction II
In continuation of our study of novel quinolines with anti-inflammatory activity using the Pfitzinger reaction, several new quinoline derivatives were synthesized and tested for their anti-inflammatory and ulcerogenic effect. A docking study on the COX-2
El-Feky, Said A. H.,Abd El-Samii, Zakaria K.,Osman, Nermine A.,Lashine, Jasmine,Kamel, Mohamed A.,Thabet, Hamdy Kh.
p. 104 - 116
(2015/02/19)
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