cas 35186-98-2, 7-HYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID | Articles data ｜lookchem

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35186-98-2

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ISOQUINOLINE DERIVATIVES
The present invention relates to isoquinoline derivatives of formula (I), the use of the compounds of formula (I), as inhibitors of one or more kinases, the use of the compounds of formula (I), for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
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Page/Page column 114-115

(2010/02/13)

Synthesis of 7-phenylethoxy-1,2,3,4-tetrahydroiso- quinoline derivatives
Synthesis of 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives is described, from diiodotyrosine, using a Pictet-Spengler reaction and further O-alkylation of the aromatic ring providing compounds (1) and (2).
Caubert, Virginie,Viaud-Massuard, Marie-Claude
p. 175 - 180
(2007/10/03)

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864236-90-8
C₂₁H₁₈F₄N₄O₂

Chemical Properties

Boiling Point: 456.3 °C at 760 mmHg
Flash Point:229.8 °C
Density: 1.351g/cm³
PSA: 69.56000
LogP: 0.81990

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