- GLYCOLATE OXIDASE INHIBITORS AND USE THEREOF
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The present invention provides pyrazoles, isoxazoles, isothiazoles, thiadiazoles, and pyridazines according to Formula I as described herein, and pharmaceutically acceptable salts thereof. Pharmaceutical compositions and methods for treating primary hyperoxaluria, type I (PH) and kidney stones are also described.
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Paragraph 0150
(2019/07/17)
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- Novel synthesis of anthelmintic drug 4-isothiocyanato-4′- nitrodiphenyl ether and its analogs
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An efficient, mild, chemoselective, and convenient protocol for synthesis of isothiocyanate derivatives. This protocol was applied successfully in the novel synthesis of anthelmintic drug 4-isothiocyanato-4′-nitrodiphenyl ether and its analogs. Copyright Taylor & Francis Group, LLC.
- Chaskar,Bandgar,Modhave,Patil,Yewale
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body text
p. 992 - 1001
(2009/09/08)
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- Identification of novel, selective and potent Chk2 inhibitors
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A series of isothiazole carboxamidine compounds were synthesized and discovered as novel and selective inhibitors for Chk2. They are not active against the related Chk1 kinase. The structure-activity relationship studies were performed on the scaffold, an
- Larson, Gary,Yan, Shunqi,Chen, Huanming,Rong, Frank,Hong, Zhi,Wu, Jim Zhen
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p. 172 - 175
(2007/10/03)
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- Novel derivatives of benzimidazole and imidazo-pyridine and their use as medicaments
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A compound of the formula wherein the substituents are as defined in the specification and pharmaceutical salts thereof having a good affinity for sub-types of melanocortin receptors making them useful for treating diseases in which such receptors are included such as pain, inflammatory conditions, etc.
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Page/Page column 12-14
(2008/06/13)
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