35212-90-9

Basic information

• Product Name: CBI-BB ZERO/001711
• Synonyms: CBI-BB ZERO/001711;Methyl 3-amino-6-nitro-1-benzothiophene-2-carboxylate;3-Amino-6-nitro-benzo[b]thiophene-2-carboxylic acid methyl ester
• CAS NO: 35212-90-9
• Molecular Formula: C₁₀H₈N₂O₄S
• Molecular Weight: 252.25
• Mol File: 35212-90-9.mol

Chemical Properties

• Melting Point: 231-232°
• Boiling Point: 450.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.528±0.06 g/cm3(Predicted)
• PKA: -0.39±0.10(Predicted)
• CAS DataBase Reference: CBI-BB ZERO/001711(CAS DataBase Reference)
• NIST Chemistry Reference: CBI-BB ZERO/001711(35212-90-9)
• EPA Substance Registry System: CBI-BB ZERO/001711(35212-90-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 35212-90-9(Hazardous Substances Data)

Upstream product

• 4110-33-2 2,4-dinitrobenzonitrile 
• 584-08-7 potassium carbonate 
• 623-51-8 ethyl 2-sulfanylacetate 
• 350-32-3 2-fluoro-4-nitrobenzamide 
• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 34667-88-4 2-fluoro-4-nitrobenzonitrile 
• 2365-48-2 Methyl thioglycolate 

Relevant articles and documents

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Microwave irradiation of 2-halobenzonitriles and methyl thioglycolate in the presence of triethylamine in DMSO at 130°C provides rapid access to 3-aminobenzo[b]thiophenes in 58-96% yield. This transformation has been applied in the synthesis of the thieno

Irreversible inhibitors of tyrosine kinases

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Synthesis of [1]Benzothieno[3,2-d]pyrimidines Substituted with Electron Donating Substituents on the Benzene Ring

Various 2-fluorobenzonitriles were converted to the corresponding 3-amino[1]benzothiophenecarboxylic acid esters, which in turn were annulated with formamidine or various equivalents to produce the desired tricyclic benzothienopyrimidines. Various methoxy and nitro/amino substituants were placed on the phenyl ring, requiring several different strategies to prepare the desired benzothiophenes. Several different pyrimidone annulations were also required. The use of an electron rich 2-bromobenzonitrile in a four-step one-pot low temperature lithiation sequence to produce highly electron-rich amino[1]benzothiophenecarboxylate esters is also described. The synthesis of 7-amino-8-fluoro[1]benzothieno[3,2-d]pyrimid-4(3H)-one was relatively straightforward, but synthesis of the corresponding 7-amino-8-protio analogue proved to be very difficult, and required several approaches before a successful one was found.

TRICYCLIC SUBSTITUTED HEXAHYDROBENZ [E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS

The present invention relates to a compound of the formula STR1 and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an α-1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are . alpha.-1 antagonist compositions and a method for antagonizing α-1 receptors and treating BPH.