35229-84-6

Basic information

• Product Name: ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE
• Synonyms: ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE;Ethyl 2-chloro-2-{2-[3-(trifluoromethyl)phenyl]-;Ethyl chloro{[3-(trifluoromethyl)-phenyl]hydrazono}acetate;ethyl (2Z)-2-chloro-2-{2-[3-(trifluoromethyl)phenyl]hydrazin-1-ylidene}acetate
• CAS NO: 35229-84-6
• Molecular Formula: C₁₁H₁₀ClF₃N₂O₂
• Molecular Weight: 294.66
• Mol File: 35229-84-6.mol

Chemical Properties

• Melting Point: 131-133 °C(Solv: ethanol (64-17-5))
• Boiling Point: 312°C at 760 mmHg
• Flash Point: 142.5°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 0.000545mmHg at 25°C
• Refractive Index: 1.498
• PKA: 10.77±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE(35229-84-6)
• EPA Substance Registry System: ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE(35229-84-6)

Safety Data

• Hazardous Substances Data: 35229-84-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE is used as a reagent in organic synthesis for its ability to contribute to the formation of more complex organic molecules, facilitating the creation of a wide range of chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE is utilized as a key intermediate in the development of new drugs. Its unique structure allows it to be a promising candidate for the synthesis of pharmaceutically active compounds.
Used in Material Development:
Due to its potential reactivity and structural attributes, ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE may also be employed in the development of new materials, where its properties could be leveraged to create innovative substances with specific applications.
It is crucial to handle ETHYL 2-CHLORO-2-(2-[3-(TRIFLUOROMETHYL)PHENYL]-HYDRAZONO)ACETATE with care, adhering to all safety protocols and guidelines to ensure safe usage in research and industrial settings.

InChI:InChI=1/C11H10ClF3N2O2/c1-2-19-10(18)9(12)17-16-8-5-3-4-7(6-8)11(13,14)15/h3-6,16H,2H2,1H3/b17-9+

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 105-39-5 chloroacetic acid ethyl ester 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 96734-81-5 5-Thiophen-2-yl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester 
• 96734-76-8 5-Methyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester 
• 96722-74-6 5-Phenyl-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester 
• 96734-74-6 1-(3-trifluoromethylphenyl)-3-carbethoxy-5-isobutylpyrazole 
• 96734-73-5 1-(3-trifluoromethylphenyl)-3-carbethoxy-5-(2-thienyl)pyrazole 
• 96734-82-6 ethyl 4-acetyl-5-methyl-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylate 
• 96723-28-3 1-(3-trifluoromethylphenyl)-3-carbethoxy-4-cyano-5-aminopyrazole 
• 96722-98-4 5-(3-Bromo-phenyl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid diethyl ester 
• 1000576-65-7 ethyl 5-oxo-1-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1H-1,2,4-triazole-3-carboxylate 
• 96723-19-2 5-(4-Nitro-phenyl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid 
• 96734-60-0 5-(3-Bromo-phenyl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-3,4-dicarboxylic acid 
• 96723-40-9 1-(3-trifluoromethylphenyl)-3-carboxy-5-(2-thienyl)pyrazole 

Relevant articles and documents

A new method for the synthesis of 1-aryl-1,2,4-triazole derivatives

A new and convenient one-step recyclization method for the synthesis of ethyl 1-aryl-5-oxo-4,5-dihydro-1H-1,2,4-triazole-3-carboxylates is reported. Various ethyl chloro(2-arylhydrazinylidene)ethanoates react with thiazolidine-2,4-dione in the presence of potassium hydroxide to produce the 1-aryl-1,2,4-triazole derivatives in moderate to good yields. The procedure is economical, environmentally friendly and simple to perform. Georg Thieme Verlag Stuttgart - New York.