Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists
Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid–leucine–arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block
Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly
A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational Enrichment) strategy for generatin
Kinetics and mechanism of dehydrochlorination of N-aryl-C-ethoxycarbonylformohydrazidoyl chlorides
The kinetics of triethylamine (TEA) catalyzed dehydrochlorination of a series of N-aryl-C-ethoxycarbonylformohydrazidoyl chlorides 1a-m have been studied under pseudo-first-order conditions in 4:1 (v/v) dioxane-water solution at 30 deg C.For all compounds
Shawali, Ahmad S.,Albar, Hassan A.
p. 871 - 875
(2007/10/02)
Phytotoxic activity in pyrazole derivatives. I
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Bernard,Cocco,Maccioni,Plumitallo
p. 259 - 271
(2007/10/02)
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