352520-31-1

Basic information

• Product Name: 2-nitrobenzaldehyde 5H-[1,2,4]triazino[5,6-b]indol-3-ylhydrazone
• Synonyms: 2-nitrobenzaldehyde 5H-[1,2,4]triazino[5,6-b]indol-3-ylhydrazone
• CAS NO: 352520-31-1
• Molecular Formula: C₁₆H₁₁N₇O₂
• Molecular Weight: 333.30424
• Mol File: 352520-31-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-nitrobenzaldehyde 5H-[1,2,4]triazino[5,6-b]indol-3-ylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitrobenzaldehyde 5H-[1,2,4]triazino[5,6-b]indol-3-ylhydrazone(352520-31-1)
• EPA Substance Registry System: 2-nitrobenzaldehyde 5H-[1,2,4]triazino[5,6-b]indol-3-ylhydrazone(352520-31-1)

Safety Data

• Hazardous Substances Data: 352520-31-1(Hazardous Substances Data)

Upstream product

• 31523-22-5 3-hydrazino-5H-[1,2,4]triazino[5,6-b]indole 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 1170720-79-2 1-(2-nitro)phenyl-10H-[1,2,4]triazolo[3',4':3,4][1,2,4]triazino[5,6-b]indole 

Relevant articles and documents

Syntheses and in vitro biological screening of 1-aryl-10H-[1,2,4] triazolo[3′,4′:3,4][1,2,4]triazino[5,6-b]indoles

Structurally diverse 1-aryl-10H-[1,2,4]triazolo[3′,4′:3,4][1,2, 4]triazino[5,6-b]indoles 4a-v were synthesized by regiospecific heterocyclizations. The designed molecular diversity was evaluated in vitro in parallel cell-based assays for cytotoxicity of viruses multiplication supporting cell lines and antiviral activity against viruses representative of two of three genera of the Flaviviridae family. The compound library was also tested against Retrovirus (HIV-1), two Picornaviruses (CVB-2 and Sb-1), and Paramyxoviridae (VSV) representative. Among double-stranded RNA (dsRNA) viruses, Reoviridae representative (Reo-1) was tested. Two representatives of DNA virus families were also included - HSV-1 (Herpesviridae) and VV (Poxviridae). The compounds 4m and 4o were found cytotoxic, having CC50 values ranging from 4 to 30 μM. Moreover, compound 4v has exhibited significant activity (EC50 = 3 μM) against BVDV.