- NEW COMPOUNDS AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME
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The present invention relates to a novel compound and an organic luminescent device containing the novel compound in an organic compound layer, wherein the compound improves the life, efficiency, electrochemical stability, and thermal stability of the organic luminescent device. In chemical formula 1, R1 and R2 are selected from a group consisting of an alkyl group having 1-10 carbons and an aryl group having 6-30 carbons.
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Paragraph 0110-0113
(2017/04/19)
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- COMPOUNDS AND METHODS OF USE
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This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGFβ) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.
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Paragraph 0130
(2015/07/16)
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- Design and application of a low-temperature continuous flow chemistry platform
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A flow reactor platform technology applicable to a broad range of low temperature chemistry is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume. The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.
- Newby, James A.,Blaylock, D. Wayne,Witt, Paul M.,Pastre, Julio C.,Zacharova, Marija K.,Ley, Steven V.,Browne, Duncan L.
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p. 1211 - 1220
(2014/12/10)
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- The expedient synthesis of 4,2′-difluoro-5′-(7- trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile, a GABA α2/3 agonist
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An expedient regioselective synthesis of a GABA α2/3 agonist 1 is described. The key step is an efficient regioselective palladium-catalyzed coupling of 7-trifluoromethylimidazo[1,2-a]pyrimidine (5) to 5′-chloro-4,2′-difluorobiphenyl-2-carbonitrile (15).
- Cameron, Mark,Foster, Bruce S.,Lynch, Joseph E.,Shi, Yao-Jun,Dolling, Ulf-H.
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p. 398 - 402
(2012/12/22)
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