- Straightforward syntheses of furanomycin derivatives and their biological evaluation
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Several types of furanomycin analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its desmethyl derivative showed antibacterial activity, pointing towards a narrow structure-activity relationship.
- Kazmaier, Uli,Paehler, Saskia,Endermann, Rainer,Haebich, Dieter,Kroll, Hein-Peter,Riedl, Bernd
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- Protected amino hydroxy adamantane carboxylic acid and process for its preparation
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Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided. The provided compounds can be used for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent.
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Paragraph 0337-0339; 0432; 0433
(2015/11/24)
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