353256-69-6Relevant articles and documents
Selective N-Monoalkylation of 6-Aminouracils with Alcohols: An Environmentally Benign Protocol for the Synthesis of 6-Alkylaminouracils
Putra, Anggi Eka,Oe, Yohei,Ohta, Tetsuo
, p. 392 - 397 (2018)
A highly selective N-alkylation of 6-aminouracils with alcohols was achieved through the borrowing hydrogen approach using iridium catalysis. 6-Aminouracils and alcohols reacted in the presence of [Cp*IrI2]2 to give 6-monoalkyluracils selectively and in high yield (up to 99 %), usually in short reaction times (2 h). These results provide a new, green, and efficient protocol for the synthesis of 6-alkylaminouracils, which are very important intermediates for the synthesis of biologically active molecules.
