- Phenyl pyrrole compound and application thereof in bactericidal activity
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The invention provides a novel phenyl pyrrole compound, and the phenyl pyrrole compound shows good bactericidal activity and can be used for preparing a broad-spectrum plant bactericide. In addition,the synthesis route is simple, the operation is convenient, the synthesis cost is reduced, and ecological environment pollution to soil, surface water, underground water and the like is avoided.
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Paragraph 0143-0144
(2020/08/17)
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- Nitrogen-substituted phenyl pyrrole compound and application thereof in plant sterilization
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The invention provides a novel nitrogen-substituted phenyl pyrrole compound. The phenyl pyrrole compound shows good bactericidal activity and can be used for preparing bactericides with high-selectivity sterilization. Moreover, the synthesis route is simple, the operation is convenient, the synthesis cost is reduced, and ecological environment pollution to soil, surface water, underground water and the like is avoided.
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Paragraph 0143; 0159-0160
(2020/07/21)
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- Cascade Synthesis of 2-Cyanoacrylamides through Deacetalization and/or Knoevenagel Condensation followed by Selective Monohydration of Acetals and Aldehydes over Solid Acid Ferrites
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A new protocol of cascade synthesis for biologically active 2-cyanoacrylamides (1) was developed. The reaction proceeds over a novel magnetically retrievable solid-acid composite of iron oxide, poly(vinylpyrrolidone) and phosphotungstic acid (Fe3O4/PVP–PWA) in AcOH–H2O medium under reflux conditions. This transformation is facilitated through single-site Br?nsted acid catalyzed cascade reactions involving deacetalization and/or Knoevenagel condensation followed by selective monohydration of nitriles starting from acetals (5) and aldehydes (2) with malononitrile (3). A series of aldehydes, dimethyl and diethyl acetals, along with some heterocyclic aldehydes were successfully transformed to 2-cyanoacrylamides with >95 % yields. TEM images confirmed the coating of the PVP over nanosized Fe3O4. Stereoselective monohydration of 2-benzylidenemalononitriles (4) to E isomers was demonstrated by NOESY experiments. The catalyst could be efficiently recycled seven times on employment of both acetals and aldehydes as substrates, as a result of its magnetic nature.
- Kamble, Sumit B.,Rode, Chandrashekhar V.
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p. 2678 - 2687
(2016/08/30)
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- Tuning the Electronic Properties of 2-Cyano-3-phenylacrylamide Derivatives
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We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C=O?H-N-C=O?H-N?); i.e., dimers are linked through dimeric N-H?O hydrogen bonds. The single-crystal X-ray structure shows molecules to be hydrogen-bonded dimers, which further form a parallel stacking arrangement, mediated by significant π-π interactions. The 1H NMR and fluorescence spectral studies indicate the coexistence of amide and iminol tautomers in solution, which can be influenced by the nature of the solvent. Further, the excitation-wavelength-dependent fluorescence spectrum and the biexponential fluorescence decay profiles suggest the presence of more than one emitting species; i.e., amide and iminol tautomers coexists in solution. We have also shown that the equilibrium between the two tautomers can be tuned by the judicious choice of electron-donating or -withdrawing substituents.
- Gunasekar, Ramachandran,Thamaraiselvi, Pichandi,Rathore, Ravindranath S.,Sathiyanarayanan, Kulathu Iyer,Easwaramoorthi, Shanmugam
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p. 12351 - 12358
(2016/01/09)
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- Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles
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α,α-Dicyanoolefins react with hydroxylamine to afford 2,3-dihydroisoxazoles (2,3-dihydroisoxazoles can be easily isolated by filtration) in excellent yields under mild and environmentally benign conditions. A one-pot reaction in tandem with an unexpected ring-opening of 2,3-dihydroisoxazoles has been developed as well.
- Li, Ping,Teng, Bo-Tao,Jin, Fa-Gen,Li, Xin-Sheng,Zhu, Wei-Dong,Xie, Jian-Wu
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p. 244 - 247
(2012/01/19)
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- Condensation reactions of aromatic aldehydes with active methylene compounds catalyzed by alkaline ionic liquid
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The Knoevenagel condensation reactions of aromatic aldehydes with active methylene compounds catalyzed by the functionalized ionic liquid, 1-n-butyl-3-methylimmidazolium hydroxide ([bmim]OH), were carried out under grinding, heating, and microwave irradia
- Wang, Dong-Yue,Xi, Guo-Hong,Ma, Jing-Jun,Wang, Chun,Zhang, Xiao-Chao,Wang, Qian-Qian
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experimental part
p. 3060 - 3065
(2011/09/12)
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