- Preparation method for aryl acetone compounds
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The invention belongs to the field of organic synthesis, and specifically relates to a preparation method for aryl acetone compounds. A technical scheme of the invention is as follows: (1) with 2-methyl-3-arylacrylic acid as a starting material, carrying out a catalytic reaction of the starting material and thionyl chloride in an organic solvent through a catalyst so as to obtain 2-methyl-3-aryl acryloyl chloride, carrying out reduced pressure distillation so as to remove the organic solvent, then adding methanol, and carrying out a reaction so as to obtain methyl 2-methyl-3-arylacrylate; (2) adding hydrazine hydrate with a concentration of 80% into a reaction solution in the step 1, and carrying out a reaction so as to obtain a 2-methyl-3-aryl acrylyl hydrazine; and (3) subjecting a reaction solution in the step 2 to reduced pressure distillation so as to remove methanol, then adding the organic solvent and diluted hydrochloric acid and carrying out stirring, taking sodium nitrite and carrying out preparing into an aqueous solution, and dropwise adding the aqueous solution of sodium nitrite into a system under stirring so as to prepare aryl acetone. The method provided by the invention has the advantages of low production cost, mild reaction conditions, simple operation, high yield, and applicability to industrial production.
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Paragraph 0036; 0037
(2017/03/08)
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