35454-01-4Relevant articles and documents
Oxidative Coupling of Diazo and NH4I: A Route to Primary Oxamates and α-Ketoamides
Fang, Shangwen,Li, Jingjing,Wan, Xiaobing,Wang, Hanghang,Zhao, Yanwei,Zheng, Yonggao
supporting information, p. 3050 - 3058 (2020/03/23)
A simple and efficient method has been developed for the preparation of primary oxamates and α-ketoamides through the oxidative coupling of diazo compounds and NH4I. Under the optimized reaction conditions, a range of diazoesters and α-diazoketones was explored, and the corresponding products were obtained in moderate to good yields. This protocol is metal-free, is performed under mild conditions, has a wide substrate scope, and offers operational simplicity.
Method for preparing oxamide ester
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Paragraph 0018-0019, (2019/09/05)
The invention discloses a method for preparing oxamide ester. A diazonium ester compound and ammonium iodide are adopted as reaction substrates, t-butylhydroperoxide (TBHP) is adopted as an environment-friendly oxidant under the condition of having no transition metal and alkali, and the oxamide ester is obtained through an oxidative coupling reaction in an organic solvent. Compared with the priorart, the method has the following advantages that the range of the reaction substrates is wide, reaction conditions are mild, the operation is simple, and the environment is protected. According to the method, TBHP is used as the oxidant, tert-butanol and water are produced after the reaction, the use of oxidants such as iodobenzene acetate and sodium hypochlorite is avoided, no harm is caused tothe environment, and the requirements of contemporary environment-friendly chemistry are met. In addition, the method can be used for post-modification of natural active molecules, such as cholesterol and epiandrosterone, a final target product with a high yield can be obtained, and a foundation is laid for practical application.
