354824-17-2

Basic information

• Product Name: 5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE
• Synonyms: 5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE;6-(DiMethylaMino)-3-pyridineMethanaMine
• CAS NO: 354824-17-2
• Molecular Formula: C₈H₁₃N₃
• Molecular Weight: 151.21
• Mol File: 354824-17-2.mol

Chemical Properties

• Boiling Point: 282.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.075±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.18±0.29(Predicted)
• CAS DataBase Reference: 5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE(354824-17-2)
• EPA Substance Registry System: 5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE(354824-17-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 354824-17-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE is used as a synthetic intermediate for the preparation of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. These inhibitors have potential therapeutic applications in the treatment of diseases such as cancer.
As a synthetic intermediate, 5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE plays a crucial role in the development of new drugs targeting NAMPT, an enzyme involved in the regulation of cellular metabolism and energy homeostasis. Inhibition of NAMPT has been shown to have potential anti-cancer effects by disrupting the metabolic pathways in cancer cells, leading to their growth arrest and apoptosis.
Furthermore, the unique structure of 5-(AMINOMETHYL)-N,N-DIMETHYLPYRIDIN-2-AMINE allows for the design and synthesis of novel NAMPT inhibitors with improved potency, selectivity, and pharmacokinetic properties. This can lead to the development of more effective cancer therapies with fewer side effects and better patient outcomes.

Upstream product

• 36507-21-8 6-(dimethylamino)pyridine-3-carboxamide 
• 154924-17-1 N'-(5-cyanopyridin-2-yl)-N,N-dimethylformamidine 
• 33252-28-7 6-chloronicotinonitrile 

Downstream Products

• 1073428-69-9 5-chloro-2-{4-[(6-dimethylamino-pyridin-3-ylmethyl)-amino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl}-benzonitrile 
• 1363132-11-9 (1-((6-dimethylamino)pyridin-3-yl)methyl)-3-(4-(phenylsulfonyl)phenyl)urea 

Relevant articles and documents

4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL] AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties

A series of novel 2-cyanoacrylates containing different aromatic rings were synthesized, and their structures were characterized by 1H NMR, elemental analysis, and single-crystal X-ray diffraction analysis. Their herbicidal activities against four weeds and inhibition of photosynthetic electron transport against isolated chloroplasts (the Hill reaction) were evaluated. Both in vivo and in vitro data showed that the compounds containing benzene, pyridine, and thiazole moieties gave higher activities than those containing pyrimidine, pyridazine, furan, and tetrahedronfuran moieties. To further explore the comprehensive structure-activity relationship on the basis of in vitro data, comparative molecular field analysis (CoMFA) was performed, and the results showed that a bulky and electronegative group around the para-position of the aromatic rings would have the potential for higher activity, which offered important structural insights into designing highly active compounds prior to the next synthesis.