355114-74-8

Basic information

• Product Name: 1H-Pyrrole,1-(2-methyl-2-propenyl)-(9CI)
• Synonyms: 1H-Pyrrole,1-(2-methyl-2-propenyl)-(9CI)
• CAS NO: 355114-74-8
• Molecular Formula: C₈H₁₁N
• Molecular Weight: 121.17964
• Product Categories: AMINETERTIARY
• Mol File: 355114-74-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole,1-(2-methyl-2-propenyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole,1-(2-methyl-2-propenyl)-(9CI)(355114-74-8)
• EPA Substance Registry System: 1H-Pyrrole,1-(2-methyl-2-propenyl)-(9CI)(355114-74-8)

Safety Data

• Hazardous Substances Data: 355114-74-8(Hazardous Substances Data)

Upstream product

• 109-97-7 pyrrole 
• 563-47-3 3-Chloro-2-methylpropene 

Downstream Products

• 355114-79-3 6-methyl-5,6-dihydroindonizine 

Relevant articles and documents

Synthesis of 5,6,7,8-tetrahydroindolizines via a domino-type transformation based on the rhodium catalyzed hydroformylation of N-(β-methallyl)pyrroles

(Chemical Equation Presented) Variously substituted 5,6,7,8- tetrahydroindolizines can be easily synthesized via a domino reactions sequence under rhodium catalyzed hydroformylation of N-(β-methallyl)pyrroles. The later are readily prepared from properly functionalized pyrroles via phase-transfer N-allylation in the presence of 18-crown-6 and potassium tert-butoxide.

An original approach to 5,6-dihydroindolizines from 1-allylpyrroles by a tandem hydroformylation/cyclization/dehydration sequence

6-Methyl-5,6-dihydroindolizine and 3- or 2-ethyl derivatives were obtained via a one-pot hydroformylation/cyclization/dehydration sequence starting from 1-(2-methyl-2-propenyl)pyrroles. 7-Phenyl-5,6-dihydroindolizine and 5-methyl-5,6-dihydroindolizine were similarly synthesized. An easily occurring electrophilic aromatic substitution by the carbon atom of the carbonyl group on the α-position of the pyrrole ring with the formation of the six-membered ring is the key-step of the process.