Sequence-selective peptide recognition with designed modules
A concept for the rational design of sequence-selective peptide receptors has been extended: in addition to recognition modules for polar, aromatic and basic amino acids, the series has now been completed with new receptor units for apolar and acidic amin
Wehner, Mark,Janssen, Dominic,Schaefer, Gerhard,Schrader, Thomas
SERINE REPLACEMENT POLYMYXIN ANALOGUES USEFUL AS ANTIBIOTIC POTENTIATORS
The disclosure provides compounds of the formula I or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables R1 and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering a therapeutically effective amount of the antibacterial agent and a compound of formula I to a patient infected with the bacteria, simultaneously or sequentially.
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Paragraph 0238
(2017/12/09)
IsN-acetylornithine aminotransferase the real N-succinyl-LL-diaminopimelate aminotransferase in Escherichia coli and Mycobacterium smegmatis?
We examined the similarities and differences between the activities of N-succinyl-LL-diaminopimelate aminotransferase (DAP-AT) and N-acetylornithine aminotransferase (NAcO-AT) from E. coli and M. smegmatis in order to investigate recent claims that the tw
Cox,Wang
p. 2006 - 2008
(2007/10/03)
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