Synthesis of (R)-serine-2-d and its conversion to the broad spectrum antibiotic fludalanine
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Reider,Eichen Conn,Davis,et al.
p. 3326 - 3334
(2007/10/02)
Fluorodesulfurization of alkyl mercaptans or alkyl dithianes
Organic compounds containing a mercapto group or a dithiane moiety can be transformed into the analogous fluoro or difluoro compounds by reacting them with a halogenating reagent in liquid hydrogen fluoride, optionally containing boron trifluoride or antimony pentafluoride solution, at temperatures from about -80° and 15° C. The method may be descriptively termed "fluorodesulfurization".
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(2008/06/13)
Process for preparing 3-fluoro-D-alanine and its deutero analogs
3-Fluoro-D-alanine and its deutero analogs, which are potent antibacterial agents, are prepared from fluoropyruvic acid by asymmetric synthesis using an optically active amine such as D-α-methyl-benzylamine.
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(2008/06/13)
Processes for asymmetric conversion of 3-fluoro-L-alanine and 2-deutero-3-fluoro-L-alanine to their D-isomers
3-Fluoro-L-alanine is transformed by asymmetric conversion, via an intermediate L-2-(halo)-3-fluoropropionic acid, to 3-fluoro-D-alanine. The 3-fluoro-D-alanine thus obtained is a potent antibacterial agent.
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(2008/06/13)
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