cas 35565-06-1, (6R-cis)-3-(acetoxymethyl)-7-methoxy-8-oxo-7-(2-thienylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | Articles data ｜lookchem

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35565-06-1

Articles about 35565-06-1Total 4 be found

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Application of Mefoxin (cefoxitin sodium) pharmaceutical preparation in infection prevention in gastrointestinal surgery
The present invention provides cefoxitin sodium or a composition thereof, a preparation process of the cefoxitin sodium or the composition thereof, a prescribed preparation, a compound preparation, and use. In the cefoxitin sodium or the composition thereof, the mass content of the cefoxitin (C16H17N3O7S2) is 92% or above on an anhydrous basis. The cefoxitin sodium or the composition thereof has good quality stability and a uniform particle size range, can reduce the process difficulty for preparing preparations, can improve clinical curative effects and safety, and can be used for gastrointestinal surgery infection prevention and postoperative infection treatment.
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Paragraph 0133; 0134; 0138; 0139; 0143; 0144

(2019/11/13)

Reactions of TMSI with cephalosporin esters
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Bonjouklian,Phillips
p. 3915 - 3918
(2007/10/02)

Process for etherifying β-lactam antibiotics
6-Alkoxylated-6-acylamidopenicillanic acids and 7-alkoxylated-7-acylamidocephalosporin acids and esters thereof, are provided by reacting a 6-acylamidopenicillanic acid ester or a 7-acylamidocephalosporin ester under anhydrous conditions at -90° C. to -15° C. with an alkali metal salt of a lower alkyl alcohol in the presence of an excess of the corresponding alcohol to produce, in situ, the anionic form of the antibiotic which on halogenation with a positive halogen compound, e.g. t-butyl hypochlorite, yields the compound of the invention. Compounds of the invention, e.g. 6-methoxy-6-phenoxyacetamidopenicillanic acid and 7-methoxy-7-[2-(2-thienyl)acetamido]cephalosporanic acid are useful antibiotics.
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(2008/06/13)

Total synthesis of β lactam antibiotics III. (±) cefoxitin
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Ratcliffe,Christensen
p. 4653 - 4656
(2007/10/10)

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Chemical Properties

Boiling Point: 753.5 °C at 760 mmHg
Flash Point:409.5 °C
Density: 1.55 g/cm³
Refractive Index: 1.66
PKA: 2.70±0.50(Predicted)
PSA: 179.27000
LogP: 1.34460

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