Discovery of N -(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4- trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): An orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist
The design, synthesis, and structure-activity relationships of a novel series of pyrazines, acting as corticotropin releasing factor-1 (CRF-1) receptor antagonists, are described. Synthetic methodologies were developed to prepare a number of substituted p
Hodgetts, Kevin J.,Ge, Ping,Yoon, Taeyoung,Lombaert, Stéphane De,Brodbeck, Robbin,Gulianello, Michael,Kieltyka, Andrzej,Horvath, Raymond F.,Kehne, John H.,Krause, James E.,Maynard, George D.,Hoffman, Diane,Lee, Younglim,Fung, Laurence,Doller, Dario
p. 4187 - 4206
(2011/08/21)
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