356085-57-9

Basic information

• Product Name: 1-(2,5-DIMETHOXY-BENZYL)-PIPERAZINE
• Synonyms: 1-(2,5-DIMETHOXY-BENZYL)-PIPERAZINE;TIMTEC-BB SBB011749;1-(2,5-DiMethoxybenzyl)piperazine 2HCl
• CAS NO: 356085-57-9
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.31
• Mol File: 356085-57-9.mol

Chemical Properties

• Boiling Point: 351.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.074±0.06 g/cm3(Predicted)
• PKA: 9.11±0.10(Predicted)
• CAS DataBase Reference: 1-(2,5-DIMETHOXY-BENZYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,5-DIMETHOXY-BENZYL)-PIPERAZINE(356085-57-9)
• EPA Substance Registry System: 1-(2,5-DIMETHOXY-BENZYL)-PIPERAZINE(356085-57-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 356085-57-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(2,5-DIMETHOXY-BENZYL)-PIPERAZINE is used as a precursor for the synthesis of other compounds due to its potential pharmacological activities. Its unique chemical structure allows for the development of new drugs with various therapeutic applications.
Used in Biotechnological Industry:
1-(2,5-DIMETHOXY-BENZYL)-PIPERAZINE is used as a research compound for exploring its potential role as a psychoactive substance. Its study contributes to the understanding of its effects on the central nervous system and its potential use in the development of novel therapeutic agents for neurological disorders.

Upstream product

• 110-85-0 piperazine 
• 3840-27-5 2,5-dimethoxybenzyl chloride 

Downstream Products

• 1075725-73-3 N'-(3-allyl-2-hydroxybenzylidene)-2-(4-(2,5-dimethoxybenzyl)piperazin-1-yl)acetohydrazide 
• 1075725-72-2 2-(4-(2,5-dimethoxybenzyl)piperazin-1-yl)-N'-(2-hydroxybenzylidene) acetohydrazide 
• 1075725-84-6 2-(4-(2,5-dimethoxybenzyl)piperazin-1-yl)acetohydrazide 

Relevant articles and documents

Design, synthesis and SAR of antitubercular benzylpiperazine ureas

Abstract: N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres Cantos molecules with a phenyl ring led to molecule (I) with an MIC of 1?μM against Mtb H37Rv, low cellular toxicity (HepG2 IC50 ~ 80?μM), good DMPK properties and specificity for Mtb. With the aim of delineating the SAR associated with (I), fifty-five analogs were synthesized and screened against Mtb. The SAR suggests that the piperazine ring, benzyl urea and piperonyl moieties are essential signatures of this series. Active compounds in this series are metabolically stable, have low cellular toxicity and are valuable leads for optimization. Molecular docking suggests these molecules occupy the Q0 site of QcrB like Q203. Graphic Abstract: Bioisosteric replacement of N-furfuryl piperazine-1-carboxamides yielded molecule (I) a novel lead with satisfactory PD, metabolism, and toxicity profiles.[Figure not available: see fulltext.]

COMPOSITIONS AND METHODS INCLUDING CELL DEATH INDUCERS AND PROCASPASE ACTIVATION

Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.