356531-35-6

Basic information

• Product Name: N-(2-BROMOPHENYLMETHYL)TERT-BUTYLAMINE
• Synonyms: N-(2-BROMOPHENYLMETHYL)TERT-BUTYLAMINE;UKRORGSYN-BB BBV-083145
• CAS NO: 356531-35-6
• Molecular Formula: C₁₁H₁₆BrN
• Molecular Weight: 242.16
• Mol File: 356531-35-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-BROMOPHENYLMETHYL)TERT-BUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-BROMOPHENYLMETHYL)TERT-BUTYLAMINE(356531-35-6)
• EPA Substance Registry System: N-(2-BROMOPHENYLMETHYL)TERT-BUTYLAMINE(356531-35-6)

Safety Data

• Hazardous Substances Data: 356531-35-6(Hazardous Substances Data)

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 

Relevant articles and documents

A tandem Heck-aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines

A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.

Synthesis of Medium Ring Nitrogen Heterocycles via a Tandem Copper-Catalyzed C-N Bond Formation-Ring-Expansion Process

A simple method for the preparation of medium ring heterocycles (7-, 8-, 9-, and 10-membered) has been developed. The process employs a Cu-catalyzed coupling of a β-lactam with an aryl bromide or iodide followed by intramolecular attack of a pendant amino group. In some instances, the intermediate β-lactam is observable but can be converted to the aza-heterocycle by catalysis. Acetic acid was found to be superior to transition metal complexes as a catalyst for this ring-expansion process.