Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: Improvement of cell potency
A series of anilino(imidazoquinoxaline) analogues bearing solubilizing side chains at the 6- and 7-positions of the fused phenyl ring has been prepared and evaluated for inhibition against Lck enzyme and of T-cell proliferation. Significant improvement of the cellular activity was achieved over the initial lead, compound 2.
Chen, Ping,Iwanowicz, Edwin J.,Norris, Derek,Gu, Henry H.,Lin, James,Moquin, Robert V.,Das, Jagabandhu,Wityak, John,Spergel, Steven H.,De Fex, Henry,Pang, Suhong,Pitt, Sydney,Shen, Ding Ren,Schieven, Gary L.,Barrish, Joel C.
p. 3153 - 3156
(2007/10/03)
Synthesis of imidazo[1,5-a]quinoxalin-4(5H)-one template via a novel intramolecular cyclization process
A novel, efficient, and regiospecific method for the construction of the imidazo[1,5-a]quinoxalin-4(5H)-one template is described. The key reaction involves an intramolecular cyclization process and provides the desired products in excellent yield.
Norris, Derek,Chen, Ping,Barrish, Joel C.,Das, Jagabandhu,Moquin, Robert,Chen, Bang-Chi,Guo, Peng
p. 4297 - 4299
(2007/10/03)
More Articles about upstream products of 357647-43-9