- THERAPEUTIC AGENT FOR CEREBRAL INFARCTION
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The invention provides a therapeutic drug for ischemic stroke. The therapeutic drug has the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof, as an active ingredient.
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- PROCESS FOR PREPARING N-METHYL-3, 4-DIMETHOXYPHENYLETHYLAMINE
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Provided are intermediates useful for the preparation of verapamil and methods for their preparation.
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Page/Page column 7
(2009/07/17)
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- Compound 48/80. Structure activity relations and poly THIQ, a new, more potent analog
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Derivatives of p methoxyphenethylmethylamine were synthesized from which formaldehyde copolymers analogous to compound 48/80 were prepared. Measurement of the hypotensive activity of these analogs revealed that potency was not enhanced by changing the group in the para position, by varying the length of the alkyl group, or by altering the degree of methylation of the amine. However, when the ethylamine side chain was cyclized to form 7 methoxytetrahydroisoquinoline, the copolymer prepared from this derivative (poly THIQ) was seven times more potent than compound 48/80. The hypotensive action of poly THIQ was found to result from the liberation of histamine, as with compound 48/80.
- Read,Kiefer,Weber
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p. 1292 - 1295
(2007/10/04)
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